Nimesulide Analog; Compound 76

Code: 482210-5MG D2-231

General description

A cell-permeable sulfonanilide that is shown to exhibit an antiproliferative effect against three HER-2-positive breast cancer cell lines, SKBR-3, BT474 a...


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€247.50 EACH
€304.43 inc. VAT

General description

A cell-permeable sulfonanilide that is shown to exhibit an antiproliferative effect against three HER-2-positive breast cancer cell lines, SKBR-3, BT474 and MDA-MB-453 (IC50= 0.9, 2.2, and 4.0 µM, respectively), and affects two HER-2-negative breast cancer cell lines, MCF-7 and MDA-MB-231 only at much higher concentrations (IC50 = 22.1 and 19.6 µM, respectively). The compound is not expected to be a COX-2 inhibitor and its cellular target(s) and mechanism(s) of growth inhibition is yet to be seen.

A cell-permeable sulfonanilide that is shown to exhibit an antiproliferative effect against SKBR-3, BT474 and MDA-MB-453, and affects MCF-7 and MDA-MB-231 only at much higher concentrations.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Chen, B., et al. 2009. Biochem. Pharmacol.77, 1787. Su, B., et al. 2008. J. Comb. Chem.10, 475.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C).

Warning

Toxicity: Standard Handling (A)

assay≥95% (HPLC)
coloroff-white
formsolid
manufacturer/tradenameCalbiochem®
Quality Level100
shipped inambient
solubilityDMSO: 25 mg/mL
storage conditionOK to freeze
storage temp.2-8°C
Cas Number1021926-22-6
This product has met the following criteria to qualify for the following awards:



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