General description
A cell-permeable sulfonanilide that is shown to exhibit an antiproliferative effect against three HER-2-positive breast cancer cell lines, SKBR-3, BT474 and MDA-MB-453 (IC50= 0.9, 2.2, and 4.0 µM, respectively), and affects two HER-2-negative breast cancer cell lines, MCF-7 and MDA-MB-231 only at much higher concentrations (IC50 = 22.1 and 19.6 µM, respectively). The compound is not expected to be a COX-2 inhibitor and its cellular target(s) and mechanism(s) of growth inhibition is yet to be seen.
A cell-permeable sulfonanilide that is shown to exhibit an antiproliferative effect against SKBR-3, BT474 and MDA-MB-453, and affects MCF-7 and MDA-MB-231 only at much higher concentrations.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Chen, B., et al. 2009. Biochem. Pharmacol.77, 1787. Su, B., et al. 2008. J. Comb. Chem.10, 475.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C).
Warning
Toxicity: Standard Handling (A)
This product has met the following criteria to qualify for the following awards: